Tadalafil Side Effects
Common tadalafil side effects include headache, flushing, indigestion, and sometimes back or muscle ache. Like other PDE5 inhibitors, it must not be used with nitrates. Seek emergency care for chest pain, sudden vision or hearing changes, or an erection lasting more than four hours.
Written by Virantus Editorial Team
Medically reviewed by Virantus Clinical Team · Reviewed August 2026
Last updated August 2026
What people often notice
Headache, flushing, and stomach upset can occur. Some men report back pain or myalgia, which is discussed more often with tadalafil than with sildenafil. Effects may appear hours after a dose. Not everyone has them, and they are not proof the medicine will or will not help erections.
Daily vs as-needed side effects
Because daily and as-needed regimens use different strengths, the side-effect profile can feel different. Tell your clinician what you notice rather than switching schedules yourself. Grapefruit can affect how some medicines are metabolized — ask before assuming it is irrelevant.
Hard safety rules
Nitrates plus tadalafil can cause a dangerous drop in blood pressure. Priapism, sudden vision or hearing loss, and allergic reactions need urgent care. Share your full medication list, including recreational substances, during evaluation.
Common questions
Sources
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